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androst-4-ene-3,17-dione monooxygenase Identifiers EC number 1.14.99.12 CAS number 37256-74-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) In enzymology, an androst-4-ene-3,17-dione monooxygenase (EC 1.14.99.12) is an enzyme that catalyzes the chemical reaction androst-4-ene-3,17-dione + AH2 + O2 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O The 3 substrates of this enzyme are androst-4-ene-3,17-dione, AH2, and O2, whereas its 3 products are 3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone, A, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidorcockeductase (13-hydroxylating, lactonizing). Other names in common use include androstene-3,17-dione hydroxylase, androst-4-ene-3,17-dione 17-oxidoreductase, androst-4-ene-3,17-dione hydroxylase, androstenedione monooxygenase, and 4-androstene-3,17-dione monooxygenase. This enzyme participates in androgen and estrogen metabolism. References Prairie RL and Talalay P (1963). "Enzymatic formation of testololactone". Biochemistry 2: 203–208. doi:10.1021/bi00901a039. PMID 13985909.  This EC 1.14 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · d · e