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(February 2009) edit MYC binding protein 2 Identifiers Symbols MYCBP2; PAM; DKFZp686M08244; FLJ10106; FLJ13826; FLJ21597; FLJ21646; KIAA0916 External IDs OMIM: 610392 MGI: 2179432 HomoloGene: 9005 GeneCards: MYCBP2 Gene Gene Ontology Molecular function • protein binding • zinc ion binding • ligase activity • protein homodimerization activity • metal ion binding Cellular component • nucleus Biological process • transcription • regulation of transcription, DNA-dependent • ubiquitin cycle Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23077 105689 Ensembl ENSG00000005810 ENSMUSG00000033004 UniProt O75592 Q7TPH6 RefSeq (mRNA) NM_015057 NM_207215 RefSeq (protein) NP_055872 NP_997098 Location (UCSC) Chr 13: 76.52 - 76.8 Mb Chr 14: 102 - 102.23 Mb PubMed search [1] [2] Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.[1][2] PAM contains a N-terminal leucine zipper, central MYC-binding, and C-termainl histone-binding protein homology domains.[1] Interactions MYCBP2 has been shown to interact with Myc.[1] References ^ a b c Guo Q, Xie J, Dang CV, Liu ET, Bishop JM (Sep 1998). "Identification of a large Myc-binding protein that contains RCC1-like repeats". Proc Natl Acad Sci U S A 95 (16): 9172–7. doi:10.1073/pnas.95.16.9172. PMID 9689053.  ^ "Entrez Gene: MYCBP2 MYC binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23077.  Further reading Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.  Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.  Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMID 11042152.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Murthy V, Han S, Beauchamp RL, et al. (2004). "Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex.". J. Biol. Chem. 279 (2): 1351–8. doi:10.1074/jbc.M310208200. PMID 14559897.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.  Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.  Pierre SC, Häusler J, Birod K, et al. (2005). "PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.". EMBO J. 23 (15): 3031–40. doi:10.1038/sj.emboj.7600321. PMID 15257286.  Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.  Gao X, Patel TB (2005). "Histidine residues 912 and 913 in protein associated with Myc are necessary for the inhibition of adenylyl cyclase activity.". Mol. Pharmacol. 67 (1): 42–9. doi:10.1124/mol.104.005355. PMID 15470080.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.  Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  This article on a gene on chromosome 13 is a stub. You can help Wikipedia by expanding it. v • d • e