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This article needs attention from an expert on the subject. See the talk page for details. WikiProject Pharmacology or the Pharmacology Portal may be able to help recruit an expert. (February 2009) Cyclopentenone prostaglandin (cyPG) is a type of prostaglandin, a molecule which regulates inflammation and other processes. It is a potential new target for anti-inflammatory actions. It is thought to prevent the inflammatory pathway by inhibiting the activation of NF-κB, a transcription factor in cell reproduction. The cyclopentenone prostaglandin known as 15d-PGJ2 has been shown to inhibit a gene in T cells which is active in inflammation, such as in various autoimmune diseases.[1][2] References ^ Fionda, C., et al. (2007). Inhibition of Trail gene expression by cyclopentenonic prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T lymphocytes. Molecular Pharmacology 72:5 1246-57. ^ Cernuda-Morollón, E., et al. (2001). 15-Deoxy-Δ12,14-prostaglandin J2 Inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. Journal of Biological Chemistry 276 35530-36. This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it. v • d • e