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mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) Identifiers Symbol MASP1 Alt. symbols CRARF, PRSS5 Entrez 5648 HUGO 6901 OMIM 600521 RefSeq NM_001879 UniProt P48740 Other data Locus Chr. 3 q27-q28 Mannose-binding lectin-associated protein of 44 kDa (MAp44) is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin pathway activation, by displacing MASP-2 from MBL, hence preventing cleavage of C4 and C2 [1] See also mannan-binding lectin lectin pathway References ^ Degn, Søren; Annette G. Hansen, Rudi Steffensen,Christian Jacobsen, Jens C. Jensenius and Steffen Thiel (November 2009). "MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation". Journal of Immunology 183 (11): 7371–7378. doi:10.4049/jimmunol.0902388. PMID 19917686. http://www.jimmunol.org/cgi/content/full/183/11/7371.  External links MeSH MASP+Proteases v · d · eProteins: complement system (C, L, A) Activators/enzymes Early C: C1Q/C1R/C1S - C4 (C4a) - C2 L: MASP1/MASP2 - MBL A: Factor B - Factor D - Factor P/Properdin Middle C3 (C3a, C3b/iC3b) - C5 (C5a) C3-convertase - C5-convertase Late MAC (C6, C7, C8, C9) Inhibitors CLA: C1-inhibitor - Decay-accelerating factor/CD59 - Factor I CL: C4BP A: Factor H Complement receptors CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) M: LMC cell/phys/auag/auab/comp, igrc imdf/ipig/hyps/tumr proc, drug(L3/4) v · d · eEndopeptidases: serine proteases/serine endopeptidases (EC 3.4.21) Digestive enzymes Enteropeptidase · Trypsin · Chymotrypsin · Elastase (Neutrophil, Pancreatic) Coagulation factors: Thrombin · Factor VIIa · Factor IXa · Factor Xa · Factor XIa · Factor XIIa · Kallikrein (PSA, KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15) fibrinolysis: Plasmin · Plasminogen activator (Tissue plasminogen activator · Urinary plasminogen activator) Complement system Factor B · Factor D · Factor I · MASP (MASP1, MASP2) · C3-convertase Other immune system Chymase · Granzyme · Tryptase · Proteinase 3/Myeloblastin Venombin Ancrod · Batroxobin Other Acrosin · Prolyl endopeptidase · Pronase · Proprotein convertases (1, 2) · Reelin · Subtilisin/Furin · Streptokinase · S1P · Cathepsin (A, G) B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6 This article on a gene on chromosome 3 is a stub. You can help Wikipedia by expanding it.v · d · e